Abstract

The study of the anticholinesterase properties of Mareya micrantha, a plant used in African pharmacopoeia as a laxative, was carried out on cholinesterases of the rabbit duodenum. At 0.15 mg / ml, the aqueous extract (MAR), its fraction (F5) and its sub-fraction (F52), depending on their state of purity, decrease the catalytic speed of cholinesterases during the hydrolysis of the acetylthiocholine (ASCh), without significantly influencing the Michaelis constant. The sub-fraction (F52) with the best anti-cholinesterase and myostimulant effects revealed by the bio-guided study is 25% more effective than MAR. A study of the High performance liquid chromatography (HPLC) chromatogram of this sub-fraction F52 shows that this plant is rich in phenolic molecules.">

    Abstracting and Indexing

  • PubMed NLM
  • Chemical Abstract Service (CAS)
  • Publons
  • Index Medicus (IMSEAR)
  • Google Scholar
  • ResearchGate
  • Genamics
  • Academic Keys
  • Enugu State University of Science and Technology
  • DRJI
  • Microsoft Academic
  • Academia.edu
  • OpenAIRE
  • Semantic Scholar

Anticholinesterase Properties of Mareya Micrantha (Benth) Mull. Arg. (Euphorbiaceae) and its Fractions on the Cholinesterase Model of Isolated Rabbit Duodenum

Author(s): Mamadou Dosso, Tianga Yaya Soro, Michel Archange Libra, Flavien Traore, Jean David N’guessan

Abstract

The study of the anticholinesterase properties of Mareya micrantha, a plant used in African pharmacopoeia as a laxative, was carried out on cholinesterases of the rabbit duodenum. At 0.15 mg / ml, the aqueous extract (MAR), its fraction (F5) and its sub-fraction (F52), depending on their state of purity, decrease the catalytic speed of cholinesterases during the hydrolysis of the acetylthiocholine (ASCh), without significantly influencing the Michaelis constant. The sub-fraction (F52) with the best anti-cholinesterase and myostimulant effects revealed by the bio-guided study is 25% more effective than MAR. A study of the High performance liquid chromatography (HPLC) chromatogram of this sub-fraction F52 shows that this plant is rich in phenolic molecules.

    Editor In Chief

    Jean-Marie Exbrayat

  • General Biology-Reproduction and Comparative Development,
    Lyon Catholic University (UCLy),
    Ecole Pratique des Hautes Etudes,
    Lyon, France

© 2016-2019, Copyrights Fortune. All Rights Reserved